Archive for the ‘Uncategorized’ Category


Research priorities during infectious disease emergencies in West Africa

Tuesday, March 13th, 2018

Abstract

Objectives:

This paper presents the results of the consultations conducted with various stakeholders in Africa and other experts to document community perspectives on the types of research to be prioritised in outbreak conditions. The Delphi method was used to distill consensus.

Results:

Our consultations highlighted as key, the notion that in an infectious disease outbreak situation, the need to establish an evidence base on how to reduce morbidity and mortality in real time takes precedence over the production of generalizable knowledge. Research studies that foster understanding of how disease transmission could be prevented in the future remain important, implementation research that explores how to mitigate the impact of outbreaks in the present should be prioritized. Clinical trials aiming to establish the safety profile of therapeutic interventions should be limited during the acute phase of an epidemic with high fatality-and should preferably use adaptive designs. We concluded that community members have valuable perspectives to share about research priorities during infectious disease emergencies. Well designed consultative processes could help identify these opinions.

Keywords:

Consultation; Epidemic; Infectious disease; Research design; Research priorities; West Africa

Land-Locked Developing Countries and Their Infrastructural Challenges in Contributing to Global Ethics: A Zimbabwe Case Study

Tuesday, October 31st, 2017

Research Ethics Committees in Nigeria: A Survey of Operations, Functions, and Needs

Thursday, August 31st, 2017

Abstract: Heightened global commitment to research on diseases such as HIV/AIDS, tuberculosis, and malaria has led to increased research over the past decade in many African countries, including Nigeria. This increase in research has led to debates about the ethics of health research in resource-poor or developing countries and has drawn further attention to existing ethical review processes. This study was undertaken to describe and benchmark the operational and organizational structures as well as functions of research ethics committees (RECs) in Nigeria. The article explores the factors that contribute to REC conformity with the Nigerian National Ethics Code and World Health Organization (WHO) guidelines for RECs. Data were collected using a self-administered, semistructured questionnaire. A descriptive analysis was conducted, and Fisher’s exact tests performed to assess associations between selected REC characteristics and the degree of conformity to applicable national and international requirements. Eighty percent of RECs (20 out of 25) had standard operating procedures, while 68% (17 out of 25) met at least quarterly and provided final review determinations within three months. RECs with committee chairs who had prior bioethics training were more likely to have operations conforming to the WHO and the Nigerian ethics guidelines. Overall, this study suggests that there is variability in the degree to which operations and functions of RECs in Nigeria conform to the Nigerian National Code and WHO guidelines.

 

Research Ethics Committees in Nigeria: A Survey of Operations, Functions, and Needs,. Aminu A. Yakubu, Adnan A. Hyder, Joseph Ali, and Nancy Kass. IRB: Ethics & Human Research. 2017. May-June 2017 Volume: 39, Issue: 3

Addressing ethical issues in H3Africa research–the views of research ethics committee members

Saturday, October 31st, 2015

* de Vries J, Abayomi A, Littler K, Madden E, McCurdy S, Oukem-Boyer OOM, Seeley J, Staunton C, Tangwa G, Tindana P:  Addressing ethical issues in H3Africa research–the views of research ethics committee members. Hugo J 2015, 1(9):1-4.

Applying ethical principles to international community-based research: A case study from the consortium to respond effectively to the AIDS-TB epidemic (CREATE).

Thursday, May 22nd, 2014

Assessing the quality of informed consent in a resource-limited setting: A cross-sectional study

Monday, August 27th, 2012